A Non-VH1-69 Heterosubtypic Neutralizing Human Monoclonal Antibody Protects Mice against H1N1 and H5N1 Viruses
Identifieur interne : 000A93 ( Main/Exploration ); précédent : 000A92; suivant : 000A94A Non-VH1-69 Heterosubtypic Neutralizing Human Monoclonal Antibody Protects Mice against H1N1 and H5N1 Viruses
Auteurs : Donata De Marco [Italie] ; Nicola Clementi [Italie] ; Nicasio Mancini [Italie] ; Laura Solforosi [Italie] ; Guisella J. Moreno [Italie] ; Xiangjie Sun [États-Unis] ; Terrence M. Tumpey [États-Unis] ; Larisa V. Gubareva [États-Unis] ; Vasiliy Mishin [États-Unis] ; Massimo Clementi [Italie] ; Roberto Burioni [Italie]Source :
- PLoS ONE [ 1932-6203 ] ; 2012.
Abstract
Influenza viruses are among the most important human pathogens and are responsible for annual epidemics and sporadic, potentially devastating pandemics. The humoral immune response plays an important role in the defense against these viruses, providing protection mainly by producing antibodies directed against the hemagglutinin (HA) glycoprotein. However, their high genetic variability allows the virus to evade the host immune response and the potential protection offered by seasonal vaccines. The emergence of resistance to antiviral drugs in recent years further limits the options available for the control of influenza. The development of alternative strategies for influenza prophylaxis and therapy is therefore urgently needed. In this study, we describe a human monoclonal antibody (PN-SIA49) that recognizes a highly conserved epitope located on the stem region of the HA and able to neutralize a broad spectrum of influenza viruses belonging to different subtypes (H1, H2 and H5). Furthermore, we describe its protective activity in mice after lethal challenge with H1N1 and H5N1 viruses suggesting a potential application in the treatment of influenza virus infections.
Url:
DOI: 10.1371/journal.pone.0034415
PubMed: 22496802
PubMed Central: 3319592
Affiliations:
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The humoral immune response plays an important role in the defense against these viruses, providing protection mainly by producing antibodies directed against the hemagglutinin (HA) glycoprotein. However, their high genetic variability allows the virus to evade the host immune response and the potential protection offered by seasonal vaccines. The emergence of resistance to antiviral drugs in recent years further limits the options available for the control of influenza. The development of alternative strategies for influenza prophylaxis and therapy is therefore urgently needed. In this study, we describe a human monoclonal antibody (PN-SIA49) that recognizes a highly conserved epitope located on the stem region of the HA and able to neutralize a broad spectrum of influenza viruses belonging to different subtypes (H1, H2 and H5). Furthermore, we describe its protective activity in mice after lethal challenge with H1N1 and H5N1 viruses suggesting a potential application in the treatment of influenza virus infections.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Thompson, Ww" uniqKey="Thompson W">WW Thompson</name></author><author><name sortKey="Shay, Dk" uniqKey="Shay D">DK Shay</name></author><author><name sortKey="Weintraub, E" uniqKey="Weintraub E">E Weintraub</name></author><author><name sortKey="Brammer, L" uniqKey="Brammer L">L Brammer</name></author><author><name sortKey="Bridges, Cb" uniqKey="Bridges C">CB Bridges</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fiore, Ae" uniqKey="Fiore A">AE Fiore</name></author><author><name sortKey="Shay, Dk" uniqKey="Shay D">DK Shay</name></author><author><name sortKey="Broder, K" uniqKey="Broder K">K Broder</name></author><author><name sortKey="Iskander, Jk" 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uniqKey="Burioni R" first="Roberto" last="Burioni">Roberto Burioni</name><name sortKey="Clementi, Massimo" sort="Clementi, Massimo" uniqKey="Clementi M" first="Massimo" last="Clementi">Massimo Clementi</name><name sortKey="Clementi, Nicola" sort="Clementi, Nicola" uniqKey="Clementi N" first="Nicola" last="Clementi">Nicola Clementi</name><name sortKey="Mancini, Nicasio" sort="Mancini, Nicasio" uniqKey="Mancini N" first="Nicasio" last="Mancini">Nicasio Mancini</name><name sortKey="Moreno, Guisella J" sort="Moreno, Guisella J" uniqKey="Moreno G" first="Guisella J." last="Moreno">Guisella J. Moreno</name><name sortKey="Solforosi, Laura" sort="Solforosi, Laura" uniqKey="Solforosi L" first="Laura" last="Solforosi">Laura Solforosi</name></country><country name="États-Unis"><region name="Géorgie (États-Unis)"><name sortKey="Sun, Xiangjie" sort="Sun, Xiangjie" uniqKey="Sun X" first="Xiangjie" last="Sun">Xiangjie Sun</name></region><name sortKey="Gubareva, Larisa V" sort="Gubareva, Larisa V" uniqKey="Gubareva L" first="Larisa V." last="Gubareva">Larisa V. Gubareva</name><name sortKey="Mishin, Vasiliy" sort="Mishin, Vasiliy" uniqKey="Mishin V" first="Vasiliy" last="Mishin">Vasiliy Mishin</name><name sortKey="Tumpey, Terrence M" sort="Tumpey, Terrence M" uniqKey="Tumpey T" first="Terrence M." last="Tumpey">Terrence M. Tumpey</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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